反应详情

To a vigorously stirred suspension of compound 2-[(3-isopropyl-1,2,4-oxadiazol-5-yl)methyl]-1H-isoindole-1,3(2H)-dione (79 g, 0.29 mol) in ethanol (500 mL), hydrazine hydrate (16 g, 0.32 mol) was added. After the precipitate was completely dissolved, the reaction mixture was heated to reflux for 4 h. The precipitate was removed by filtration. The mother liquor was evaporated. The residue was dissolved in ether (200 mL). The precipitate was removed by filtration. The filtrate was evaporated. The residue was redistilled under high vacuum collecting the fraction boiling at 62-65° C./0.02 mmHg to yield the title compound.

1. additionwas added
2. dissolutionAfter the precipitate was completely dissolved
3. temperaturethe reaction mixture was heated
4. temperatureto reflux for 4 h
5. customThe precipitate was removed by filtration
6. customThe mother liquor was evaporated
7. dissolutionThe residue was dissolved in ether (200 mL)
8. customThe precipitate was removed by filtration
9. customThe filtrate was evaporated
10. distillationThe residue was redistilled under high vacuum
11. customcollecting the fraction boiling at 62-65° C./0.02 mmHg