2-Amino-5-(4-fluorophenyl)thiophene-3-carboxamide → tert-Butyl[(6-{[3-(aminocarbonyl)-5-(4-fluorophenyl)-2-thienyl]amino}pyridin-2-yl)methyl]methylcarbamate

HRID 385775Notes

Reaction equation

HRID 385775 reaction equation
[C:1]([O:5][C:6](=[O:17])[N:7]([CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12](Br)[N:11]=1)[CH3:8])([CH3:4])([CH3:3])[CH3:2].[NH2:18][C:19]1[S:20][C:21]([C:27]2[CH:32]=[CH:31][C:30]([F:33])=[CH:29][CH:28]=2)=[CH:22][C:23]=1[C:24]([NH2:26])=[O:25]>>[C:1]([O:5][C:6](=[O:17])[N:7]([CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([NH:18][C:19]2[S:20][C:21]([C:27]3[CH:32]=[CH:31][C:30]([F:33])=[CH:29][CH:28]=3)=[CH:22][C:23]=2[C:24]([NH2:26])=[O:25])[N:11]=1)[CH3:8])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 99427712-Amino-5-(4-fluorophenyl)thiophene-3-carboxamideHCID 59525776tert-Butyl ((6-bromopyridin-2-yl)methyl)(methyl)carbamate

Product 1

HCID 59525661tert-Butyl[(6-{[3-(aminocarbonyl)-5-(4-fluorophenyl)-2-thienyl]amino}pyridin-2-yl)methyl]methylcarbamate

Procedure

The title compound was prepared according to the general procedure in Example 1 using tert-butyl[(6-bromopyridin-2-yl)methyl]methylcarbamate (90.0 mg, 0.299 mmol) and 2-amino-5-(4-fluorophenyl)thiophene-3-carboxamide (78.0 mg, 0.329 mmol) as the starting materials.

Sources & evidence

ORD record
ord-7c3c1932674c406eaa91687c1448593c
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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