HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-5-(4-fluorophenyl)thiophene-3-carboxamide → tert-Butyl[(6-{[3-(aminocarbonyl)-5-(4-fluorophenyl)-2-thienyl]amino}pyridin-2-yl)methyl]methylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-5-(4-fluorophenyl)thiophene-3-carboxamide | HCID 9942771 | — |
| Reactant | tert-Butyl ((6-bromopyridin-2-yl)methyl)(methyl)carbamate | HCID 59525776 | — |
| Product | tert-Butyl[(6-{[3-(aminocarbonyl)-5-(4-fluorophenyl)-2-thienyl]amino}pyridin-2-yl)methyl]methylcarbamate | HCID 59525661 | — |
Reaction Steps
The title compound was prepared according to the general procedure in Example 1 using tert-butyl[(6-bromopyridin-2-yl)methyl]methylcarbamate (90.0 mg, 0.299 mmol) and 2-amino-5-(4-fluorophenyl)thiophene-3-carboxamide (78.0 mg, 0.329 mmol) as the starting materials.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08367706B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-7c3c1932674c406eaa91687c1448593c |
| Source note | uspto-grants-2013_02 |