2-Amino-5-(4-fluorophenyl)thiophene-3-carboxamide → 5-(4-Fluorophenyl)-2-{[6-(1-pyrrolidin-1-ylethyl)pyridin-2-yl]amino}thiophene-3-carboxamide

HRID 385787Notes

Reaction equation

HRID 385787 reaction equation
Br[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH:8]([N:10]2[CH2:14][CH2:13][CH2:12][CH2:11]2)[CH3:9])[N:3]=1.[NH2:15][C:16]1[S:17][C:18]([C:24]2[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=2)=[CH:19][C:20]=1[C:21]([NH2:23])=[O:22]>>[F:30][C:27]1[CH:26]=[CH:25][C:24]([C:18]2[S:17][C:16]([NH:15][C:2]3[CH:7]=[CH:6][CH:5]=[C:4]([CH:8]([N:10]4[CH2:14][CH2:13][CH2:12][CH2:11]4)[CH3:9])[N:3]=3)=[C:20]([C:21]([NH2:23])=[O:22])[CH:19]=2)=[CH:29][CH:28]=1

Participants

3

Reactant 2

HCID 99427712-Amino-5-(4-fluorophenyl)thiophene-3-carboxamideHCID 595262232-Bromo-6-(1-pyrrolidin-1-ylethyl)pyridine

Product 1

HCID 595258445-(4-Fluorophenyl)-2-{[6-(1-pyrrolidin-1-ylethyl)pyridin-2-yl]amino}thiophene-3-carboxamide

Procedure

The title compound was prepared according to the general procedure in Example 1 using 2-bromo-6-(1-pyrrolidin-1-ylethyl)pyridine (200 mg, 0.78 mmol) and 2-amino-5-(4-fluorophenyl)thiophene-3-carboxamide (204 mg, 0.86 mmol) as the starting materials.

Sources & evidence

ORD record
ord-b078e240e30d4d7db6b86c7272e2ef68
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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