HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-5-(4-fluorophenyl)thiophene-3-carboxamide → 5-(4-Fluorophenyl)-2-{[6-(1-pyrrolidin-1-ylethyl)pyridin-2-yl]amino}thiophene-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-5-(4-fluorophenyl)thiophene-3-carboxamide | HCID 9942771 | — |
| Reactant | 2-Bromo-6-(1-pyrrolidin-1-ylethyl)pyridine | HCID 59526223 | — |
| Product | 5-(4-Fluorophenyl)-2-{[6-(1-pyrrolidin-1-ylethyl)pyridin-2-yl]amino}thiophene-3-carboxamide | HCID 59525844 | — |
Reaction Steps
The title compound was prepared according to the general procedure in Example 1 using 2-bromo-6-(1-pyrrolidin-1-ylethyl)pyridine (200 mg, 0.78 mmol) and 2-amino-5-(4-fluorophenyl)thiophene-3-carboxamide (204 mg, 0.86 mmol) as the starting materials.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08367706B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-b078e240e30d4d7db6b86c7272e2ef68 |
| Source note | uspto-grants-2013_02 |