2-Amino-5-(4-fluorophenyl)thiophene-3-carboxamide → 2-{[6-(1-Azetidin-1-ylethyl)pyridin-2-yl]amino}-5-(4-fluorophenyl)thiophene-3-carboxamide

HRID 385789Notes

Reaction equation

HRID 385789 reaction equation
[N:1]1([CH:5]([C:7]2[CH:12]=[CH:11][CH:10]=[C:9](Br)[N:8]=2)[CH3:6])[CH2:4][CH2:3][CH2:2]1.[NH2:14][C:15]1[S:16][C:17]([C:23]2[CH:28]=[CH:27][C:26]([F:29])=[CH:25][CH:24]=2)=[CH:18][C:19]=1[C:20]([NH2:22])=[O:21]>>[N:1]1([CH:5]([C:7]2[N:8]=[C:9]([NH:14][C:15]3[S:16][C:17]([C:23]4[CH:28]=[CH:27][C:26]([F:29])=[CH:25][CH:24]=4)=[CH:18][C:19]=3[C:20]([NH2:22])=[O:21])[CH:10]=[CH:11][CH:12]=2)[CH3:6])[CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 99427712-Amino-5-(4-fluorophenyl)thiophene-3-carboxamideHCID 595255652-(1-Azetidin-1-ylethyl)-6-bromopyridine

Product 1

HCID 595256682-{[6-(1-Azetidin-1-ylethyl)pyridin-2-yl]amino}-5-(4-fluorophenyl)thiophene-3-carboxamide

Procedure

The title compound was prepared according to the general procedure in Example 1 using 2-(1-azetidin-1-ylethyl)-6-bromopyridine (200 mg, 0.83 mmol) and 2-amino-5-(4-fluorophenyl)thiophene-3-carboxamide (216 mg, 0.91 mmol) as the starting materials.

Sources & evidence

ORD record
ord-9c6f717968d1463fa8b33ad994daa41b
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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