HRID385802

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(O)c1cc(F)c(-c2cc(C(N)=O)c(N)s2)c(F)c1

HCID59525619

未命名化合物

HCID59525637

未命名化合物

PRODUCTS

生成物

结构：CC(C)(O)c1cc(F)c(-c2cc(C(N)=O)c(Nc3cccc(CC(O)C4CCS(=O)(=O)CC4)n3)s2)c(F)c1

HCID59526215

未命名化合物

PROCEDURE

实验过程

The title compound was prepared according to the general procedure in Example 1 using 2-(6-bromopyridin-2-yl)-1-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)ethanol (0.11 g, 0.32 mmol) and 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (0.10 g, 0.32 mmol) as the starting materials.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b75a95c8bfe340b7a4854f89ccee5f65
来源数据集: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08367706B2
来源说明: uspto-grants-2013_02

反应 SMILES

Br[C:2]1[N:7]=[C:6]([CH2:8][CH:9]([CH:11]2[CH2:16][CH2:15][S:14](=[O:18])(=[O:17])[CH2:13][CH2:12]2)[OH:10])[CH:5]=[CH:4][CH:3]=1.[NH2:19][C:20]1[S:21][C:22]([C:28]2[C:33]([F:34])=[CH:32][C:31]([C:35]([OH:38])([CH3:37])[CH3:36])=[CH:30][C:29]=2[F:39])=[CH:23][C:24]=1[C:25]([NH2:27])=[O:26]>>[F:39][C:29]1[CH:30]=[C:31]([C:35]([OH:38])([CH3:37])[CH3:36])[CH:32]=[C:33]([F:34])[C:28]=1[C:22]1[S:21][C:20]([NH:19][C:2]2[CH:3]=[CH:4][CH:5]=[C:6]([CH2:8][CH:9]([CH:11]3[CH2:16][CH2:15][S:14](=[O:18])(=[O:17])[CH2:13][CH2:12]3)[OH:10])[N:7]=2)=[C:24]([C:25]([NH2:27])=[O:26])[CH:23]=1