HRID385804

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(O)c1ccc(-c2cc(C(N)=O)c(N)s2)cc1

HCID59526212

未命名化合物

结构：CC(C)(C)OC(=O)N1CCC(C(O)c2cccc(Br)n2)CC1

HCID86646265

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)N1CCC(C(O)c2cccc(Nc3sc(-c4ccc(C(C)(C)O)cc4)cc3C(N)=O)n2)CC1

HCID59526150

未命名化合物

PROCEDURE

实验过程

The title compound was prepared as described in Example 1 with 2-amino-5-[4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (0.20 g, 0.73 mmol) and tert-butyl 4-[(6-bromopyridin-2-yl)(hydroxy)methyl]piperidine-1-carboxylate (0.27 g, 0.71 mmol) as the starting materials.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f6fb01556d9145f38e96c02df2d93c77
来源数据集: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08367706B2
来源说明: uspto-grants-2013_02

反应 SMILES

[NH2:1][C:2]1[S:3][C:4]([C:10]2[CH:15]=[CH:14][C:13]([C:16]([OH:19])([CH3:18])[CH3:17])=[CH:12][CH:11]=2)=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8].Br[C:21]1[N:26]=[C:25]([CH:27]([OH:41])[CH:28]2[CH2:33][CH2:32][N:31]([C:34]([O:36][C:37]([CH3:40])([CH3:39])[CH3:38])=[O:35])[CH2:30][CH2:29]2)[CH:24]=[CH:23][CH:22]=1>>[NH2:9][C:7]([C:6]1[CH:5]=[C:4]([C:10]2[CH:15]=[CH:14][C:13]([C:16]([OH:19])([CH3:17])[CH3:18])=[CH:12][CH:11]=2)[S:3][C:2]=1[NH:1][C:21]1[N:26]=[C:25]([CH:27]([OH:41])[CH:28]2[CH2:29][CH2:30][N:31]([C:34]([O:36][C:37]([CH3:39])([CH3:38])[CH3:40])=[O:35])[CH2:32][CH2:33]2)[CH:24]=[CH:23][CH:22]=1)=[O:8]