2-Amino-5-[4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → tert-Butyl 4-[[6-({3-(aminocarbonyl)-5-[4-(1-hydroxy-1-methylethyl)phenyl]-2-thienyl}amino)pyridin-2-yl](hydroxy)methyl]piperidine-1-carboxylate

Participants

Reaction Steps

The title compound was prepared as described in Example 1 with 2-amino-5-[4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (0.20 g, 0.73 mmol) and tert-butyl 4-[(6-bromopyridin-2-yl)(hydroxy)methyl]piperidine-1-carboxylate (0.27 g, 0.71 mmol) as the starting materials.

Provenance & Evidence