2,6-Dibromopyridine → (6-Bromopyridin-2-yl)(tetrahydro-2H-thiopyran-4-yl)methanol

HRID 385805Notes

Reaction equation

HRID 385805 reaction equation
Br[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Br:8])[N:3]=1.[S:9]1[CH2:14][CH2:13][CH:12]([CH:15]=[O:16])[CH2:11][CH2:10]1>>[Br:8][C:4]1[N:3]=[C:2]([CH:15]([CH:12]2[CH2:13][CH2:14][S:9][CH2:10][CH2:11]2)[OH:16])[CH:7]=[CH:6][CH:5]=1

Participants

3

Reactant 2

HCID 122742,6-DibromopyridineHCID 20143720Thiane-4-carbaldehyde

Product 1

HCID 59525786(6-Bromopyridin-2-yl)(tetrahydro-2H-thiopyran-4-yl)methanol

Procedure

The title compound was prepared as described in Example 162, Step 1 with 2,6-dibromopyridine (3.64 g, 15.36 mmol) and tetrahydro-2H-thiopyran-4-carbaldehyde (2.00 g, 15.36 mmol) as the starting materials.

Sources & evidence

ORD record
ord-38a3f2e4bfa243aeab031b8c93bb4d62
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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