2-Amino-5-(4-chlorophenyl)thiophene-3-carboxamide → 5-(4-Chlorophenyl)-2-{[6-(1,2-dihydroxy-1-methylethyl)pyridin-2-yl]amino}thiophene-3-carboxamide

HRID 385812Notes

Reaction equation

HRID 385812 reaction equation
[NH2:1][C:2]1[S:3][C:4]([C:10]2[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][CH:11]=2)=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8].Br[C:18]1[N:23]=[C:22]([C:24]([OH:28])([CH3:27])[CH2:25][OH:26])[CH:21]=[CH:20][CH:19]=1>>[Cl:16][C:13]1[CH:14]=[CH:15][C:10]([C:4]2[S:3][C:2]([NH:1][C:18]3[CH:19]=[CH:20][CH:21]=[C:22]([C:24]([OH:28])([CH3:27])[CH2:25][OH:26])[N:23]=3)=[C:6]([C:7]([NH2:9])=[O:8])[CH:5]=2)=[CH:11][CH:12]=1

Participants

3

Reactant 2

HCID 99429922-Amino-5-(4-chlorophenyl)thiophene-3-carboxamideHCID 583352552-(6-Bromopyridin-2-yl)propane-1,2-diol

Product 1

HCID 595257075-(4-Chlorophenyl)-2-{[6-(1,2-dihydroxy-1-methylethyl)pyridin-2-yl]amino}thiophene-3-carboxamide

Procedure

The title compound was prepared by using the procedure described in Example 1 with 2-amino-5-(4-chlorophenyl)thiophene-3-carboxamide (240 mg, 0.95 mmol) and 2-(6-bromopyridin-2-yl)propane-1,2-diol (200 mg, 0.86 mmol) as the starting materials.

Sources & evidence

ORD record
ord-929e973d48a442a78bce05bc7a8ccd07
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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