HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-5-(4-chlorophenyl)thiophene-3-carboxamide → 5-(4-Chlorophenyl)-2-{[6-(1,2-dihydroxy-1-methylethyl)pyridin-2-yl]amino}thiophene-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-5-(4-chlorophenyl)thiophene-3-carboxamide | HCID 9942992 | — |
| Reactant | 2-(6-Bromopyridin-2-yl)propane-1,2-diol | HCID 58335255 | — |
| Product | 5-(4-Chlorophenyl)-2-{[6-(1,2-dihydroxy-1-methylethyl)pyridin-2-yl]amino}thiophene-3-carboxamide | HCID 59525707 | — |
Reaction Steps
The title compound was prepared by using the procedure described in Example 1 with 2-amino-5-(4-chlorophenyl)thiophene-3-carboxamide (240 mg, 0.95 mmol) and 2-(6-bromopyridin-2-yl)propane-1,2-diol (200 mg, 0.86 mmol) as the starting materials.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08367706B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-929e973d48a442a78bce05bc7a8ccd07 |
| Source note | uspto-grants-2013_02 |