2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → HCID 59525963, compound

HRID 385817Notes

Reaction equation

HRID 385817 reaction equation
[NH2:1][C:2]1[S:3][C:4]([C:10]2[C:15]([F:16])=[CH:14][C:13]([C:17]([OH:20])([CH3:19])[CH3:18])=[CH:12][C:11]=2[F:21])=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8].Br[C:23]1[N:28]=[C:27]([C@@:29]2([OH:46])[CH2:34][CH2:33][N:32]([C:35]([O:37][CH2:38][C:39]3[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=3)=[O:36])[CH2:31][C@@H:30]2[OH:45])[CH:26]=[CH:25][CH:24]=1>>[NH2:9][C:7]([C:6]1[CH:5]=[C:4]([C:10]2[C:11]([F:21])=[CH:12][C:13]([C:17]([OH:20])([CH3:18])[CH3:19])=[CH:14][C:15]=2[F:16])[S:3][C:2]=1[NH:1][C:23]1[N:28]=[C:27]([C@@:29]2([OH:46])[CH2:34][CH2:33][N:32]([C:35]([O:37][CH2:38][C:39]3[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=3)=[O:36])[CH2:31][C@@H:30]2[OH:45])[CH:26]=[CH:25][CH:24]=1)=[O:8]

Participants

3

Reactant 2

HCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 59526108HCID 59526108, compound

Product 1

HCID 59525963HCID 59525963, compound

Procedure

The title compound was prepared using the procedure listed in Example 1 with 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (0.11 g, 0.34 mmol) and benzyl (3S,4S)-4-(6-bromopyridin-2-yl)-3,4-dihydroxypiperidine-1-carboxylate (0.13 g, 0.33 mmol) as the starting materials.

Sources & evidence

ORD record
ord-3daf0d118bcd48898a42db1ec321c4c2
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

Loading…