2-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → HCID 59525705, compound

HRID 385826Notes

Reaction equation

HRID 385826 reaction equation
[NH2:1][C:2]1[S:3][C:4]([C:10]2[CH:15]=[CH:14][C:13]([C:16]([OH:19])([CH3:18])[CH3:17])=[CH:12][C:11]=2[F:20])=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8].[CH2:21]([O:28][C:29](=[O:46])[N:30]([CH2:38][C:39]1[CH:44]=[CH:43][CH:42]=[C:41](Br)[N:40]=1)[CH2:31][C:32]([NH:34][CH2:35][CH2:36][OH:37])=[O:33])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>>[CH2:21]([O:28][C:29](=[O:46])[N:30]([CH2:38][C:39]1[CH:44]=[CH:43][CH:42]=[C:41]([NH:1][C:2]2[S:3][C:4]([C:10]3[CH:15]=[CH:14][C:13]([C:16]([OH:19])([CH3:17])[CH3:18])=[CH:12][C:11]=3[F:20])=[CH:5][C:6]=2[C:7]([NH2:9])=[O:8])[N:40]=1)[CH2:31][C:32]([NH:34][CH2:35][CH2:36][OH:37])=[O:33])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

Participants

3

Reactant 2

HCID 582166382-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 59526349HCID 59526349, compound

Product 1

HCID 59525705HCID 59525705, compound

Procedure

The title compound was prepared as described in Example 1 using 2-amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (50 mg, 0.17 mmol) and benzyl[(6-bromopyridin-2-yl)methyl]{2-[(2-hydroxyethyl)amino]-2-oxoethyl}carbamate (110 mg, 0.26 mmol) as starting materials.

Sources & evidence

ORD record
ord-6073b4f39cab414e961f93009a7e6c5f
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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