2-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → HCID 59526203, compound

HRID 385827Notes

Reaction equation

HRID 385827 reaction equation
[NH2:1][C:2]1[S:3][C:4]([C:10]2[CH:15]=[CH:14][C:13]([C:16]([OH:19])([CH3:18])[CH3:17])=[CH:12][C:11]=2[F:20])=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8].[CH2:21]([O:28][C:29]([N:31]([CH2:36][C:37]1[CH:42]=[CH:41][CH:40]=[C:39](Br)[N:38]=1)[CH2:32][C:33]([OH:35])=[O:34])=[O:30])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>>[NH2:9][C:7]([C:6]1[CH:5]=[C:4]([C:10]2[CH:15]=[CH:14][C:13]([C:16]([OH:19])([CH3:17])[CH3:18])=[CH:12][C:11]=2[F:20])[S:3][C:2]=1[NH:1][C:39]1[N:38]=[C:37]([CH2:36][N:31]([CH2:32][C:33]([OH:35])=[O:34])[C:29]([O:28][CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=[O:30])[CH:42]=[CH:41][CH:40]=1)=[O:8]

Participants

3

Reactant 2

HCID 582166382-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 59526017HCID 59526017, compound

Product 1

HCID 59526203HCID 59526203, compound

Procedure

The title compound was prepared as described in Example 1 with 2-amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (500 mg, 1.70 mmol) and N-[(benzyloxy)carbonyl]-N-[(6-bromopyridin-2-yl)methyl]glycine (Example 179, Step 3) (644 mg, 1.70 mmol).

Sources & evidence

ORD record
ord-14c3854b3a3b407cba3a89b7f9d6d227
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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