反应详情

温度

0 °C

4-Hydroxy-2-pyrrolidone (1.00 g, 9.89 mmol) was suspended in DMF (25 mL) and cooled to 0° C. Imidazole (1.01 g, 14.84 mmol) and TBS—Cl (1.57 g, 10.39 mmol) were added and the reaction was then warmed to room temperature. After 30 minutes the reaction was poured into water (˜50 mL) and the resulting white precipitate was collected by filtration, dried in an oven, and used without further purification.

1. temperaturethe reaction was then warmed to room temperature
2. filtrationthe resulting white precipitate was collected by filtration
3. customdried in an oven
4. customused without further purification