反应详情

(4R)-1-[(6-Bromopyridin-2-yl)methyl]-4-{[tert-butyl(dimethyl)silyl]oxy}pyrrolidin-2-one was dissolved in tetrahydrofuran (33.4 mL), and tetrabutylammonium fluoride (5.84 mL, 5.84 mmol) was added dropwise and the solution stirred at ambient temperature for five minutes. The reaction mixture was concentrated and purified by silica gel chromatography to yield the title compound.

1. concentrationThe reaction mixture was concentrated
2. custompurified by silica gel chromatography