反应详情

To a three neck 3 L round bottom flask was added 1,1-bis(bromomethyl)cyclobutane (100 g, 0.43 mol), potassium carbonate (285 g, 2.06 mol), acetonitrile (1000 mL) and ethanolamine (37.8 g, 0.62 mol). The reaction mixture was heated to reflux for 2 days. The reaction mixture was concentrated to half volume and water was added (300 mL). The aqueous layer was extracted with dichloromethane (2×500 mL). The combined organic layers were washed with brine (200 mL), dried over sodium sulfate, filtered, and concentrated to afford the title compound.

1. temperatureThe reaction mixture was heated
2. temperatureto reflux for 2 days
3. concentrationThe reaction mixture was concentrated to half volume and water
4. additionwas added (300 mL)
5. extractionThe aqueous layer was extracted with dichloromethane (2×500 mL)
6. washThe combined organic layers were washed with brine (200 mL)
7. dry with materialdried over sodium sulfate
8. filtrationfiltered
9. concentrationconcentrated