(2E)-4-(Dimethylamino)-2-butenoic acid hydrochloride → HCID 58116830, compound

HRID 38588Notes

Reaction equation

HRID 38588 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:28]=[CH:29][CH:30]=1)[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][C:11]([NH:15][C:16]3[C:17]4[C:24]5[CH2:25][NH:26][CH2:27][C:23]=5[S:22][C:18]=4[N:19]=[CH:20][N:21]=3)=[CH:12][CH:13]=2)[CH:8]=[N:7]1.Cl.[CH3:32][N:33]([CH3:40])[CH2:34]/[CH:35]=[CH:36]/[C:37](O)=[O:38]>>[CH3:32][N:33]([CH3:40])[CH2:34]/[CH:35]=[CH:36]/[C:37]([N:26]1[CH2:27][C:23]2[S:22][C:18]3[N:19]=[CH:20][N:21]=[C:16]([NH:15][C:11]4[CH:10]=[C:9]5[C:14](=[CH:13][CH:12]=4)[N:6]([CH2:5][C:4]4[CH:28]=[CH:29][CH:30]=[C:2]([F:1])[CH:3]=4)[N:7]=[CH:8]5)[C:17]=3[C:24]=2[CH2:25]1)=[O:38]

Participants

3

Reactant 2

HCID 45358758(2E)-4-(Dimethylamino)-2-butenoic acid hydrochlorideHCID 58116799HCID 58116799, compound

Product 1

HCID 58116830HCID 58116830, compound

Procedure

In analogy to Example 89, the title compound was prepared from N-[1-(3-fluorobenzyl)-1H-indazol-5-yl]-6,7-dihydro-5H-pyrrolo[3′,4′:4,5]thieno[2,3-d]pyrimidin-4-amine from Example 33A (51 mg, 0.12 mmol) and (2E)-4-(dimethylamino)but-2-enoic acid hydrochloride from Example 1A (29 mg, 0.17 mmol) to yield 30 mg (44%).

Workup

  1. customto yield 30 mg (44%)

Sources & evidence

ORD record
ord-28d8c27631fa404db4bebbb1e01162ab
Source dataset
uspto-grants-2013_09
Patent number
US08524722B2

Reaction notes

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