6-Bromopyridine-2-carboxylic acid → (2R)-4-[(6-Bromopyridin-2-yl)carbonyl]-2-methylmorpholine

HRID 385885Notes

Reaction equation

HRID 385885 reaction equation
Cl.[CH3:2][C@H:3]1[O:8][CH2:7][CH2:6][NH:5][CH2:4]1.[Br:9][C:10]1[N:15]=[C:14]([C:16](O)=[O:17])[CH:13]=[CH:12][CH:11]=1>>[Br:9][C:10]1[N:15]=[C:14]([C:16]([N:5]2[CH2:6][CH2:7][O:8][C@H:3]([CH3:2])[CH2:4]2)=[O:17])[CH:13]=[CH:12][CH:11]=1

Participants

3

Reactant 2

HCID 5939196-Bromopyridine-2-carboxylic acidHCID 42609645(2R)-2-Methylmorpholine hydrochloride

Product 1

HCID 59526327(2R)-4-[(6-Bromopyridin-2-yl)carbonyl]-2-methylmorpholine

Procedure

The title compound was prepared as described in Example 283, Step 1 using (2R)-2-methylmorpholine hydrochloride (124 mg, 0.90 mmol) and 6-bromopyridine-2-carboxylic acid (150 mg, 0.74 mmol) as starting materials.

Sources & evidence

ORD record
ord-d9f06d4a3c6348fc943ded61811e9145
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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