HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 4-(2-chloroethyl)-1-methyl-1H-pyrazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2-(1-Methyl-1H-pyrazol-4-yl)ethanol | HCID 17028076 | — |
| Product | 4-(2-chloroethyl)-1-methyl-1H-pyrazole | HCID 59525686 | — |
Reaction Steps
To excess thionyl chloride (250 mL) at 0° C. was added 2-(1-methyl-1H-pyrazol-4-yl)ethanol (82 g, 0.651 mol). The reaction mixture was heated to reflux for 15 minutes. The excess thionyl chloride was removed in vacuo and the crude product was purified by recrystallization from EtOH to afford the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08367706B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-8cf3da863bb44cb5b5e5721caf418352 |
| Source note | uspto-grants-2013_02 |