6-Bromopyridine-2-carboxylic acid → 6-Bromo-N-methyl-N-[2-(1-methyl-1H-pyrazol-3-yl)ethyl]pyridine-2-carboxamide

HRID 385890Notes

Reaction equation

HRID 385890 reaction equation
CNCC[C:5]1[CH:6]=[N:7][N:8]([CH3:10])[CH:9]=1.[Br:11][C:12]1[N:17]=[C:16]([C:18]([OH:20])=O)[CH:15]=[CH:14][CH:13]=1>>[Br:11][C:12]1[N:17]=[C:16]([C:18]([N:8]([CH3:10])[CH2:9][CH2:5][C:6]2[CH:5]=[CH:9][N:8]([CH3:10])[N:7]=2)=[O:20])[CH:15]=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 5939196-Bromopyridine-2-carboxylic acidHCID 51000371N-Methyl-2-(1-methyl-1H-pyrazol-4-yl)ethan-1-amine

Product 1

HCID 595257576-Bromo-N-methyl-N-[2-(1-methyl-1H-pyrazol-3-yl)ethyl]pyridine-2-carboxamide

Procedure

The title compound was prepared as described in Example 283, Step 1 using N-methyl-2-(1-methyl-1H-pyrazol-4-yl)ethanamine (125 mg, 0.90 mmol) and 6-bromopyridine-2-carboxylic acid (150 mg, 0.74 mmol) as starting materials.

Sources & evidence

ORD record
ord-fb2fd803312b46e5b8f2a1f3d680b615
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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