2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → HCID 59525816, compound

HRID 385893Notes

Reaction equation

HRID 385893 reaction equation
[NH2:1][C:2]1[S:3][C:4]([C:10]2[C:15]([F:16])=[CH:14][C:13]([C:17]([OH:20])([CH3:19])[CH3:18])=[CH:12][C:11]=2[F:21])=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8].Br[C:23]1[N:28]=[C:27]([CH2:29][NH:30][C:31](=[O:35])[CH2:32][C:33]#[N:34])[CH:26]=[CH:25][CH:24]=1>>[C:33]([CH2:32][C:31]([NH:30][CH2:29][C:27]1[N:28]=[C:23]([NH:1][C:2]2[S:3][C:4]([C:10]3[C:11]([F:21])=[CH:12][C:13]([C:17]([OH:20])([CH3:18])[CH3:19])=[CH:14][C:15]=3[F:16])=[CH:5][C:6]=2[C:7]([NH2:9])=[O:8])[CH:24]=[CH:25][CH:26]=1)=[O:35])#[N:34]

Participants

3

Reactant 2

HCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 59526353N-[(6-bromopyridin-2-yl)methyl]-2-cyanoacetamide

Product 1

HCID 59525816HCID 59525816, compound

Procedure

The title compound was prepared using the procedure described in Example 1 with 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (0.12 g, 0.38 mmol) and N-[(6-bromopyridin-2-yl)methyl]-2-cyanoacetamide (0.96 g, 0.38 mmol) as starting materials.

Sources & evidence

ORD record
ord-9ccb331fefdd4903b9d77dda4efbde3f
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

Loading…