Potassium Hydroxide → HCID 86646268, compound

HRID 385901Notes

Reaction equation

HRID 385901 reaction equation
[Br:1][C:2]1[N:7]=[C:6]([CH:8]([N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)[C:9]([O:11]C)=[O:10])[CH:5]=[CH:4][CH:3]=1.[OH-].[K+:20]>C1COCC1.CO>[Br:1][C:2]1[N:7]=[C:6]([CH:8]([N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)[C:9]([O-:11])=[O:10])[CH:5]=[CH:4][CH:3]=1.[K+:20]

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 59526240HCID 59526240, compound

Product 1

HCID 86646268HCID 86646268, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a solution of methyl (6-bromopyridin-2-yl)(morpholin-4-yl)acetate (1.98 g, 6.28 mmol) in THF (21 mL) and MeOH (7 mL) was added aqueous KOH (1.0 M, 6.91 mL, 6.91 mmol). The reaction was maintained at room temperature overnight and then concentrated to dryness to afford the title compound which was carried forward without purification.

Workup

  1. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-d7a0dcd399ad42dab0f43e9ce356efbf
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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