2-Chloro-5-(5-methyl-1,3,4-oxadiazol-2-yl)pyridine → 5-[2-Fluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[5-(5-methyl-1,3,4-oxadiazol-2-yl)pyridin-2-yl]amino}thiophene-3-carboxamide

HRID 385938Notes

Reaction equation

HRID 385938 reaction equation
[NH2:1][C:2]1[S:3][C:4]([C:10]2[CH:15]=[CH:14][C:13]([C:16]([OH:19])([CH3:18])[CH3:17])=[CH:12][C:11]=2[F:20])=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8].Cl[C:22]1[CH:27]=[CH:26][C:25]([C:28]2[O:29][C:30]([CH3:33])=[N:31][N:32]=2)=[CH:24][N:23]=1>>[F:20][C:11]1[CH:12]=[C:13]([C:16]([OH:19])([CH3:17])[CH3:18])[CH:14]=[CH:15][C:10]=1[C:4]1[S:3][C:2]([NH:1][C:22]2[CH:27]=[CH:26][C:25]([C:28]3[O:29][C:30]([CH3:33])=[N:31][N:32]=3)=[CH:24][N:23]=2)=[C:6]([C:7]([NH2:9])=[O:8])[CH:5]=1

Participants

3

Reactant 2

HCID 126375112-Chloro-5-(5-methyl-1,3,4-oxadiazol-2-yl)pyridineHCID 582166382-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide

Product 1

HCID 595258195-[2-Fluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[5-(5-methyl-1,3,4-oxadiazol-2-yl)pyridin-2-yl]amino}thiophene-3-carboxamide

Procedure

The title compound was prepared as described in Example 1 using 2-amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (90 mg, 0.31 mmol) and 2-chloro-5-(5-methyl-1,3,4-oxadiazol-2-yl)pyridine (60 mg, 0.31 mmol) as starting materials.

Sources & evidence

ORD record
ord-38596cfabfbd4a3a945df0643194abac
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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