4-[(6-Chloro-2-methylpyridin-3-yl)methyl]morpholine → 5-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-methyl-5-(morpholin-4-ylmethyl)pyridin-2-yl]amino}thiophene-3-carboxamide

HRID 385948Notes

Reaction equation

HRID 385948 reaction equation
Cl[C:2]1[N:7]=[C:6]([CH3:8])[C:5]([CH2:9][N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)=[CH:4][CH:3]=1.[NH2:16][C:17]1[S:18][C:19]([C:25]2[C:30]([F:31])=[CH:29][C:28]([C:32]([OH:35])([CH3:34])[CH3:33])=[CH:27][C:26]=2[F:36])=[CH:20][C:21]=1[C:22]([NH2:24])=[O:23]>>[F:36][C:26]1[CH:27]=[C:28]([C:32]([OH:35])([CH3:34])[CH3:33])[CH:29]=[C:30]([F:31])[C:25]=1[C:19]1[S:18][C:17]([NH:16][C:2]2[CH:3]=[CH:4][C:5]([CH2:9][N:10]3[CH2:15][CH2:14][O:13][CH2:12][CH2:11]3)=[C:6]([CH3:8])[N:7]=2)=[C:21]([C:22]([NH2:24])=[O:23])[CH:20]=1

Participants

3

Reactant 2

HCID 513419534-[(6-Chloro-2-methylpyridin-3-yl)methyl]morpholineHCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide

Product 1

HCID 595256595-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-methyl-5-(morpholin-4-ylmethyl)pyridin-2-yl]amino}thiophene-3-carboxamide

Procedure

The title compound was synthesized from 4-[(6-chloro-2-methylpyridin-3-yl)methyl]morpholine (90 mg, 0.40 mmol) and 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (130 mg, 0.42 mmol) according to the procedure described in Example 1.

Sources & evidence

ORD record
ord-ca0d8ce5965b426bab7be502e2a3fd6f
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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