4-[(6-Chloro-2-methylpyridin-3-yl)methyl]morpholine → 5-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-methyl-5-(morpholin-4-ylmethyl)pyridin-2-yl]amino}thiophene-3-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	4-[(6-Chloro-2-methylpyridin-3-yl)methyl]morpholine	HCID 51341953	—
Reactant	2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide	HCID 59525619	—
Product	5-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-methyl-5-(morpholin-4-ylmethyl)pyridin-2-yl]amino}thiophene-3-carboxamide	HCID 59525659	—

Reaction Steps

The title compound was synthesized from 4-[(6-chloro-2-methylpyridin-3-yl)methyl]morpholine (90 mg, 0.40 mmol) and 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (130 mg, 0.42 mmol) according to the procedure described in Example 1.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08367706B2
Source dataset	uspto-grants-2013_02
ORD ID	ord-ca0d8ce5965b426bab7be502e2a3fd6f
Source note	uspto-grants-2013_02