(2E)-4-(Dimethylamino)-2-butenoic acid hydrochloride → HCID 58116995, compound

HRID 38595Notes

Reaction equation

HRID 38595 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]2[C:15]([C:16]#[N:17])=[CH:14][N:13]=[C:12]3[S:18][C:19]4[CH2:20][NH:21][CH2:22][CH2:23][C:24]=4[C:11]=23)[CH:5]=[CH:6][C:7]=1[F:8].Cl.[CH3:26][N:27]([CH3:34])[CH2:28]/[CH:29]=[CH:30]/[C:31](O)=[O:32]>>[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]2[C:15]([C:16]#[N:17])=[CH:14][N:13]=[C:12]3[S:18][C:19]4[CH2:20][N:21]([C:31](=[O:32])/[CH:30]=[CH:29]/[CH2:28][N:27]([CH3:34])[CH3:26])[CH2:22][CH2:23][C:24]=4[C:11]=23)[CH:5]=[CH:6][C:7]=1[F:8]

Participants

3

Reactant 2

HCID 45358758(2E)-4-(Dimethylamino)-2-butenoic acid hydrochlorideHCID 581169284-[(3-Chloro-4-fluorophenyl)amino]-5,6,7,8-tetrahydrothieno[2,3-b:5,4-c']dipyridine-3-carbonitrile

Product 1

HCID 58116995HCID 58116995, compound

Procedure

In analogy to Example 89, the title compound was prepared from 4-[(3-chloro-4-fluorophenyl)amino]-5,6,7,8-tetrahydrothieno[2,3-b:5,4-c′]dipyridine-3-carbonitrile from Example 55A (100 mg, 0.28 mmol) and (2E)-4-(dimethylamino)but-2-enoic acid hydrochloride from Example 1A (65 mg, 0.39 mmol) to yield 53 mg (40%).

Workup

  1. customto yield 53 mg (40%)

Sources & evidence

ORD record
ord-da659fadd8724d72aebe764766460724
Source dataset
uspto-grants-2013_09
Patent number
US08524722B2

Reaction notes

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