(2E)-4-(Dimethylamino)-2-butenoic acid hydrochloride → 4-[(3-Chloro-4-fluorophenyl)amino]-7-[(2E)-4-(dimethylamino)but-2-enoyl]-5,6,7,8-tetrahydrothieno[2,3-b:5,4-c']dipyridine-3-carbonitrile

Participants

Reaction Steps

In analogy to Example 89, the title compound was prepared from 4-[(3-chloro-4-fluorophenyl)amino]-5,6,7,8-tetrahydrothieno[2,3-b:5,4-c′]dipyridine-3-carbonitrile from Example 55A (100 mg, 0.28 mmol) and (2E)-4-(dimethylamino)but-2-enoic acid hydrochloride from Example 1A (65 mg, 0.39 mmol) to yield 53 mg (40%).

Provenance & Evidence