反应详情

温度

80 °C

6-Chloro-2-methylnicotinic acid (Example 425, Step 1) (480 mg, 2.59 mmol) was taken up in ethanol (5.2 ml). Hydrazine (0.8 ml, 12.93 mmol) was added and the reaction was heated to 80° C. overnight. It was then concentrated under reduced pressure and purified via silica gel chromatography (0-3% methanol in ethyl acetate) to yield the title compound.

1. concentrationIt was then concentrated under reduced pressure
2. custompurified via silica gel chromatography (0-3% methanol in ethyl acetate)