Hydrazine → HCID 59526208, compound

HRID 385965Notes

Reaction equation

HRID 385965 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](O)=[O:7])=[C:4]([CH3:11])[N:3]=1.[NH2:12][NH2:13]>C(O)C>[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH:12][NH2:13])=[O:7])=[C:4]([CH3:11])[N:3]=1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 462238396-Chloro-2-methylpyridine-3-carboxylic acid

Product 1

HCID 59526208HCID 59526208, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

6-Chloro-2-methylnicotinic acid (Example 425, Step 1) (480 mg, 2.59 mmol) was taken up in ethanol (5.2 ml). Hydrazine (0.8 ml, 12.93 mmol) was added and the reaction was heated to 80° C. overnight. It was then concentrated under reduced pressure and purified via silica gel chromatography (0-3% methanol in ethyl acetate) to yield the title compound.

Workup

  1. concentrationIt was then concentrated under reduced pressure
  2. custompurified via silica gel chromatography (0-3% methanol in ethyl acetate)

Sources & evidence

ORD record
ord-a1171008c2dd4f439d6475d347bd0f01
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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