Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrazine | HCID 9321 | — |
| Reactant | 6-Chloro-2-methylpyridine-3-carboxylic acid | HCID 46223839 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 59526208 | HCID 59526208 | — |
Reaction Steps
6-Chloro-2-methylnicotinic acid (Example 425, Step 1) (480 mg, 2.59 mmol) was taken up in ethanol (5.2 ml). Hydrazine (0.8 ml, 12.93 mmol) was added and the reaction was heated to 80° C. overnight. It was then concentrated under reduced pressure and purified via silica gel chromatography (0-3% methanol in ethyl acetate) to yield the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08367706B2 |
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| Source dataset | uspto-grants-2013_02 |
|---|
| ORD ID | ord-a1171008c2dd4f439d6475d347bd0f01 |
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| Source note | uspto-grants-2013_02 |
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