2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → 5-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-methyl-5-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)pyridin-2-yl]amino}thiophene-3-carboxamide

HRID 385967Notes

Reaction equation

HRID 385967 reaction equation
[NH2:1][C:2]1[S:3][C:4]([C:10]2[C:15]([F:16])=[CH:14][C:13]([C:17]([OH:20])([CH3:19])[CH3:18])=[CH:12][C:11]=2[F:21])=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8].Cl[C:23]1[N:28]=[C:27]([CH3:29])[C:26]([C:30]2[O:34][C:33](=[O:35])[NH:32][N:31]=2)=[CH:25][CH:24]=1>>[F:16][C:15]1[CH:14]=[C:13]([C:17]([OH:20])([CH3:18])[CH3:19])[CH:12]=[C:11]([F:21])[C:10]=1[C:4]1[S:3][C:2]([NH:1][C:23]2[CH:24]=[CH:25][C:26]([C:30]3[O:34][C:33](=[O:35])[NH:32][N:31]=3)=[C:27]([CH3:29])[N:28]=2)=[C:6]([C:7]([NH2:9])=[O:8])[CH:5]=1

Participants

3

Reactant 2

HCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 59526324HCID 59526324, compound

Product 1

HCID 595262225-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-methyl-5-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)pyridin-2-yl]amino}thiophene-3-carboxamide

Procedure

The title compound was prepared as described in Example 1 using 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (150 mg, 0.48 mmol) and 5-(6-chloro-2-methylpyridin-3-yl)-1,3,4-oxadiazol-2(3H)-one (101 mg, 0.48 mmol) as starting materials.

Sources & evidence

ORD record
ord-99dc1d2536d641ad918a1a9af6e14e61
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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