2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → 5-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-methyl-5-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)pyridin-2-yl]amino}thiophene-3-carboxamide

Participants

Reaction Steps

The title compound was prepared as described in Example 1 using 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (150 mg, 0.48 mmol) and 5-(6-chloro-2-methylpyridin-3-yl)-1,3,4-oxadiazol-2(3H)-one (101 mg, 0.48 mmol) as starting materials.

Provenance & Evidence