Trifluoroacetic acid → HCID 58116906, compound

HRID 38597Notes

Reaction equation

HRID 38597 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]2[C:11]3[C:18]4[CH2:19][CH2:20][N:21]([C:23](=[O:37])/[CH:24]=[CH:25]/[CH2:26][N:27]([CH3:36])[CH2:28][C:29]([O:31]C(C)(C)C)=[O:30])[CH2:22][C:17]=4[S:16][C:12]=3[N:13]=[CH:14][N:15]=2)[CH:5]=[CH:6][C:7]=1[F:8].C(O)(C(F)(F)F)=O>C(Cl)Cl>[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]2[C:11]3[C:18]4[CH2:19][CH2:20][N:21]([C:23](=[O:37])/[CH:24]=[CH:25]/[CH2:26][N:27]([CH3:36])[CH2:28][C:29]([OH:31])=[O:30])[CH2:22][C:17]=4[S:16][C:12]=3[N:13]=[CH:14][N:15]=2)[CH:5]=[CH:6][C:7]=1[F:8]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 58116958HCID 58116958, compound

Product 1

HCID 58116906HCID 58116906, compoundYield 79.8%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
0 °C

Procedure

The compound of Example 97 (60 mg, 0.11 mmol) was dissolved in DCM (1.0 mL) and cooled to 0° C. TFA (0.30 mL) was added, and the mixture was warmed to rt and stirred overnight. Subsequently, the solvent was removed in vacuo, and the residue was purified by preparative HPLC to yield 43 mg (78%) of the title compound as white crystals.

Workup

  1. temperaturethe mixture was warmed to rt
  2. customSubsequently, the solvent was removed in vacuo
  3. customthe residue was purified by preparative HPLC

Sources & evidence

ORD record
ord-d9f23dba989348838fd236424979ae43
Source dataset
uspto-grants-2013_09
Patent number
US08524722B2

Reaction notes

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