反应详情

温度

0 °C

The compound of Example 97 (60 mg, 0.11 mmol) was dissolved in DCM (1.0 mL) and cooled to 0° C. TFA (0.30 mL) was added, and the mixture was warmed to rt and stirred overnight. Subsequently, the solvent was removed in vacuo, and the residue was purified by preparative HPLC to yield 43 mg (78%) of the title compound as white crystals.

1. temperaturethe mixture was warmed to rt
2. customSubsequently, the solvent was removed in vacuo
3. customthe residue was purified by preparative HPLC