2-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → 5-[2-Fluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-(2-fluoro-1-morpholin-4-ylethyl)pyridin-2-yl]amino}thiophene-3-carboxamide

HRID 385999Notes

Reaction equation

HRID 385999 reaction equation
Br[C:2]1[N:7]=[C:6]([CH:8]([N:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)[CH2:9][F:10])[CH:5]=[CH:4][CH:3]=1.[NH2:17][C:18]1[S:19][C:20]([C:26]2[CH:31]=[CH:30][C:29]([C:32]([OH:35])([CH3:34])[CH3:33])=[CH:28][C:27]=2[F:36])=[CH:21][C:22]=1[C:23]([NH2:25])=[O:24]>>[F:36][C:27]1[CH:28]=[C:29]([C:32]([OH:35])([CH3:33])[CH3:34])[CH:30]=[CH:31][C:26]=1[C:20]1[S:19][C:18]([NH:17][C:2]2[CH:3]=[CH:4][CH:5]=[C:6]([CH:8]([N:11]3[CH2:16][CH2:15][O:14][CH2:13][CH2:12]3)[CH2:9][F:10])[N:7]=2)=[C:22]([C:23]([NH2:25])=[O:24])[CH:21]=1

Participants

3

Reactant 2

HCID 582166382-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 595261924-[1-(6-Bromopyridin-2-yl)-2-fluoroethyl]morpholine

Product 1

HCID 595258335-[2-Fluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-(2-fluoro-1-morpholin-4-ylethyl)pyridin-2-yl]amino}thiophene-3-carboxamide

Procedure

The title compound was prepared according to the general procedure in Example 1 using 4-[1-(6-bromopyridin-2-yl)-2-fluoroethyl]morpholine (36.3 mg, 0.13 mmol) and 2-amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (37 mg, 0.13 mmol) as the starting materials.

Sources & evidence

ORD record
ord-5a96bc5483294b8ab7f4b342b372a432
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

Loading…