2-Amino-5-(6-morpholin-4-ylpyridin-3-yl)thiophene-3-carboxamide → 2-{[6-Methyl-5-(2,2,2-trifluoro-1-hydroxyethyl)pyridin-2-yl]amino}-5-(6-morpholin-4-ylpyridin-3-yl)thiophene-3-carboxamide

HRID 386006Notes

Reaction equation

HRID 386006 reaction equation
[NH2:1][C:2]1[S:3][C:4]([C:10]2[CH:11]=[N:12][C:13]([N:16]3[CH2:21][CH2:20][O:19][CH2:18][CH2:17]3)=[CH:14][CH:15]=2)=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8].Cl[C:23]1[N:28]=[C:27]([CH3:29])[C:26]([CH:30]([OH:35])[C:31]([F:34])([F:33])[F:32])=[CH:25][CH:24]=1>>[CH3:29][C:27]1[N:28]=[C:23]([NH:1][C:2]2[S:3][C:4]([C:10]3[CH:11]=[N:12][C:13]([N:16]4[CH2:21][CH2:20][O:19][CH2:18][CH2:17]4)=[CH:14][CH:15]=3)=[CH:5][C:6]=2[C:7]([NH2:9])=[O:8])[CH:24]=[CH:25][C:26]=1[CH:30]([OH:35])[C:31]([F:34])([F:32])[F:33]

Participants

3

Reactant 2

HCID 595257342-Amino-5-(6-morpholin-4-ylpyridin-3-yl)thiophene-3-carboxamideHCID 595259381-(6-Chloro-2-methylpyridin-3-yl)-2,2,2-trifluoroethanol

Product 1

HCID 595259712-{[6-Methyl-5-(2,2,2-trifluoro-1-hydroxyethyl)pyridin-2-yl]amino}-5-(6-morpholin-4-ylpyridin-3-yl)thiophene-3-carboxamide

Procedure

The title compound was prepared as described in Example 1 using 2-amino-5-(6-morpholin-4-ylpyridin-3-yl)thiophene-3-carboxamide (150 mg, 0.49 mmol) and 1-(6-chloro-2-methylpyridin-3-yl)-2,2,2-trifluoroethanol (111 mg, 0.49 mmol) as starting materials.

Sources & evidence

ORD record
ord-cd81a34d4c134d5591df5efc72e458d2
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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