HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-5-(6-morpholin-4-ylpyridin-3-yl)thiophene-3-carboxamide → 2-{[6-Methyl-5-(2,2,2-trifluoro-1-hydroxyethyl)pyridin-2-yl]amino}-5-(6-morpholin-4-ylpyridin-3-yl)thiophene-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-5-(6-morpholin-4-ylpyridin-3-yl)thiophene-3-carboxamide | HCID 59525734 | — |
| Reactant | 1-(6-Chloro-2-methylpyridin-3-yl)-2,2,2-trifluoroethanol | HCID 59525938 | — |
| Product | 2-{[6-Methyl-5-(2,2,2-trifluoro-1-hydroxyethyl)pyridin-2-yl]amino}-5-(6-morpholin-4-ylpyridin-3-yl)thiophene-3-carboxamide | HCID 59525971 | — |
Reaction Steps
The title compound was prepared as described in Example 1 using 2-amino-5-(6-morpholin-4-ylpyridin-3-yl)thiophene-3-carboxamide (150 mg, 0.49 mmol) and 1-(6-chloro-2-methylpyridin-3-yl)-2,2,2-trifluoroethanol (111 mg, 0.49 mmol) as starting materials.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08367706B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-cd81a34d4c134d5591df5efc72e458d2 |
| Source note | uspto-grants-2013_02 |