2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → HCID 59525826, compound

HRID 386019Notes

Reaction equation

HRID 386019 reaction equation
[CH3:1][O:2][C:3](=[O:14])[NH:4][CH2:5][C:6]1[C:7]([CH3:13])=[N:8][C:9](Cl)=[CH:10][CH:11]=1.[NH2:15][C:16]1[S:17][C:18]([C:24]2[C:29]([F:30])=[CH:28][C:27]([C:31]([OH:34])([CH3:33])[CH3:32])=[CH:26][C:25]=2[F:35])=[CH:19][C:20]=1[C:21]([NH2:23])=[O:22]>>[CH3:1][O:2][C:3](=[O:14])[NH:4][CH2:5][C:6]1[C:7]([CH3:13])=[N:8][C:9]([NH:15][C:16]2[S:17][C:18]([C:24]3[C:25]([F:35])=[CH:26][C:27]([C:31]([OH:34])([CH3:32])[CH3:33])=[CH:28][C:29]=3[F:30])=[CH:19][C:20]=2[C:21]([NH2:23])=[O:22])=[CH:10][CH:11]=1

Participants

3

Reactant 2

HCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 59526378HCID 59526378, compound

Product 1

HCID 59525826HCID 59525826, compound

Procedure

The title compound was synthesized from methyl[(6-chloro-2-methylpyridin-3-yl)methyl]carbamate (85 mg, 0.40 mmol) and 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (130 mg, 0.42 mmol) according to the general procedure in Example 1.

Sources & evidence

ORD record
ord-285553175e2b4d338783174bd20f0169
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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