反应详情

To a solution of 2-bromo-6-{1-[(trimethylsilyl)methyl]-1H-1,2,3-triazol-4-yl}pyridine (550 mg, 1.77 mmol) in THF (10 mL) was added TBAF (1.0 M in THF, 5.30 mL, 5.30 mmol). The reaction was stirred at room temperature for 2 h. It was subsequently diluted with water and extracted with EtOAc (2×). The combined organic layers were washed with brine, dried (MgSO4), filtered, and evaporated. Flash chromatography (20-100% EtOAc/hexanes) afforded the title compound as a colorless solid.

1. extractionextracted with EtOAc (2×)
2. washThe combined organic layers were washed with brine
3. dry with materialdried (MgSO4)
4. filtrationfiltered
5. customevaporated