2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → 5-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-(1-methyl-1H-1,2,3-triazol-4-yl)pyridin-2-yl]amino}thiophene-3-carboxamide

HRID 386061Notes

Reaction equation

HRID 386061 reaction equation
Br[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([C:8]2[N:9]=[N:10][N:11]([CH3:13])[CH:12]=2)[N:3]=1.[NH2:14][C:15]1[S:16][C:17]([C:23]2[C:28]([F:29])=[CH:27][C:26]([C:30]([OH:33])([CH3:32])[CH3:31])=[CH:25][C:24]=2[F:34])=[CH:18][C:19]=1[C:20]([NH2:22])=[O:21]>>[F:34][C:24]1[CH:25]=[C:26]([C:30]([OH:33])([CH3:32])[CH3:31])[CH:27]=[C:28]([F:29])[C:23]=1[C:17]1[S:16][C:15]([NH:14][C:2]2[CH:7]=[CH:6][CH:5]=[C:4]([C:8]3[N:9]=[N:10][N:11]([CH3:13])[CH:12]=3)[N:3]=2)=[C:19]([C:20]([NH2:22])=[O:21])[CH:18]=1

Participants

3

Reactant 2

HCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 595259902-Bromo-6-(1-methyl-1H-1,2,3-triazol-4-yl)pyridine

Product 1

HCID 595256565-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-(1-methyl-1H-1,2,3-triazol-4-yl)pyridin-2-yl]amino}thiophene-3-carboxamide

Procedure

The title compound was synthesized from 2-bromo-6-(1-methyl-1H-1,2,3-triazol-4-yl)pyridine (96 mg, 0.40 mmol) and 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (125 mg, 0.40 mmol) according to the general procedure in Example 1.

Sources & evidence

ORD record
ord-921acbecc92043548019553f4880d327
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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