HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → 5-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-(1-methyl-1H-1,2,3-triazol-4-yl)pyridin-2-yl]amino}thiophene-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide | HCID 59525619 | — |
| Reactant | 2-Bromo-6-(1-methyl-1H-1,2,3-triazol-4-yl)pyridine | HCID 59525990 | — |
| Product | 5-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-(1-methyl-1H-1,2,3-triazol-4-yl)pyridin-2-yl]amino}thiophene-3-carboxamide | HCID 59525656 | — |
Reaction Steps
The title compound was synthesized from 2-bromo-6-(1-methyl-1H-1,2,3-triazol-4-yl)pyridine (96 mg, 0.40 mmol) and 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (125 mg, 0.40 mmol) according to the general procedure in Example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08367706B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-921acbecc92043548019553f4880d327 |
| Source note | uspto-grants-2013_02 |