2-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → 5-[2-Fluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-({6-[fluoro(1-methyl-1H-1,2,3-triazol-4-yl)methyl]pyridin-2-yl}amino)thiophene-3-carboxamide

HRID 386069Notes

Reaction equation

HRID 386069 reaction equation
Br[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH:8]([F:15])[C:9]2[N:10]=[N:11][N:12]([CH3:14])[CH:13]=2)[N:3]=1.[NH2:16][C:17]1[S:18][C:19]([C:25]2[CH:30]=[CH:29][C:28]([C:31]([OH:34])([CH3:33])[CH3:32])=[CH:27][C:26]=2[F:35])=[CH:20][C:21]=1[C:22]([NH2:24])=[O:23]>>[F:35][C:26]1[CH:27]=[C:28]([C:31]([OH:34])([CH3:32])[CH3:33])[CH:29]=[CH:30][C:25]=1[C:19]1[S:18][C:17]([NH:16][C:2]2[CH:7]=[CH:6][CH:5]=[C:4]([CH:8]([F:15])[C:9]3[N:10]=[N:11][N:12]([CH3:14])[CH:13]=3)[N:3]=2)=[C:21]([C:22]([NH2:24])=[O:23])[CH:20]=1

Participants

3

Reactant 2

HCID 582166382-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 595262522-Bromo-6-[fluoro(1-methyl-1H-1,2,3-triazol-4-yl)methyl]pyridine

Product 1

HCID 595257645-[2-Fluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-({6-[fluoro(1-methyl-1H-1,2,3-triazol-4-yl)methyl]pyridin-2-yl}amino)thiophene-3-carboxamide

Procedure

The title compound was synthesized from 2-bromo-6-[fluoro(1-methyl-1H-1,2,3-triazol-4-yl)methyl]pyridine (111 mg, 0.41 mmol) and 2-amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (120 mg, 0.41 mmol) according to the general procedure in Example 1.

Sources & evidence

ORD record
ord-376ba8f879e24621b33da23225041485
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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