HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → 5-[2-Fluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-({6-[fluoro(1-methyl-1H-1,2,3-triazol-4-yl)methyl]pyridin-2-yl}amino)thiophene-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide | HCID 58216638 | — |
| Reactant | 2-Bromo-6-[fluoro(1-methyl-1H-1,2,3-triazol-4-yl)methyl]pyridine | HCID 59526252 | — |
| Product | 5-[2-Fluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-({6-[fluoro(1-methyl-1H-1,2,3-triazol-4-yl)methyl]pyridin-2-yl}amino)thiophene-3-carboxamide | HCID 59525764 | — |
Reaction Steps
The title compound was synthesized from 2-bromo-6-[fluoro(1-methyl-1H-1,2,3-triazol-4-yl)methyl]pyridine (111 mg, 0.41 mmol) and 2-amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (120 mg, 0.41 mmol) according to the general procedure in Example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08367706B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-376ba8f879e24621b33da23225041485 |
| Source note | uspto-grants-2013_02 |