2-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → 5-[2-Fluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-[(6-{1-hydroxy-1-[1-(2-hydroxyethyl)-1H-1,2,3-triazol-4-yl]ethyl}pyridin-2-yl)amino]thiophene-3-carboxamide

HRID 386074Notes

Reaction equation

HRID 386074 reaction equation
Br[C:2]1[N:7]=[C:6]([C:8]([C:11]2[N:12]=[N:13][N:14]([CH2:16][CH2:17][OH:18])[CH:15]=2)([OH:10])[CH3:9])[CH:5]=[CH:4][CH:3]=1.[NH2:19][C:20]1[S:21][C:22]([C:28]2[CH:33]=[CH:32][C:31]([C:34]([OH:37])([CH3:36])[CH3:35])=[CH:30][C:29]=2[F:38])=[CH:23][C:24]=1[C:25]([NH2:27])=[O:26]>>[F:38][C:29]1[CH:30]=[C:31]([C:34]([OH:37])([CH3:35])[CH3:36])[CH:32]=[CH:33][C:28]=1[C:22]1[S:21][C:20]([NH:19][C:2]2[CH:3]=[CH:4][CH:5]=[C:6]([C:8]([OH:10])([C:11]3[N:12]=[N:13][N:14]([CH2:16][CH2:17][OH:18])[CH:15]=3)[CH3:9])[N:7]=2)=[C:24]([C:25]([NH2:27])=[O:26])[CH:23]=1

Participants

3

Reactant 2

HCID 582166382-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 595261461-(6-Bromopyridin-2-yl)-1-[1-(2-hydroxyethyl)-1H-1,2,3-triazol-4-yl]ethanol

Product 1

HCID 595257915-[2-Fluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-[(6-{1-hydroxy-1-[1-(2-hydroxyethyl)-1H-1,2,3-triazol-4-yl]ethyl}pyridin-2-yl)amino]thiophene-3-carboxamide

Procedure

The title compound was synthesized from 1-(6-bromopyridin-2-yl)-1-[1-(2-hydroxyethyl)-1H-1,2,3-triazol-4-yl]ethanol (128 mg, 0.41 mmol) and 2-amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (120 mg, 0.41 mmol) according to the general procedure in Example 1.

Sources & evidence

ORD record
ord-39e73c43c3dc40fc960bf3bddfb307da
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

Loading…