2-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → 5-[2-Fluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-[(6-{1-hydroxy-1-[1-(2-hydroxyethyl)-1H-1,2,3-triazol-4-yl]ethyl}pyridin-2-yl)amino]thiophene-3-carboxamide

Participants

Reaction Steps

The title compound was synthesized from 1-(6-bromopyridin-2-yl)-1-[1-(2-hydroxyethyl)-1H-1,2,3-triazol-4-yl]ethanol (128 mg, 0.41 mmol) and 2-amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (120 mg, 0.41 mmol) according to the general procedure in Example 1.

Provenance & Evidence