HCID 59525582, compound → HCID 59526102, compound

HRID 386094Notes

Reaction equation

HRID 386094 reaction equation
[NH2:1][C:2]1[S:3][C:4]([C:10]2[C:15]([F:16])=[CH:14][C:13]([C:17]([OH:20])([CH3:19])[CH3:18])=[CH:12][C:11]=2[F:21])=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8].Cl[C:23]1[CH:28]=[CH:27][N:26]=[C:25]([CH2:29][N:30]2[CH2:34][CH2:33][O:32][C:31]2=[O:35])[N:24]=1.BrC1C=CN=C(CN2CCOC2=O)N=1>>[F:16][C:15]1[CH:14]=[C:13]([C:17]([OH:20])([CH3:18])[CH3:19])[CH:12]=[C:11]([F:21])[C:10]=1[C:4]1[S:3][C:2]([NH:1][C:27]2[CH:28]=[CH:23][N:24]=[C:25]([CH2:29][N:30]3[CH2:34][CH2:33][O:32][C:31]3=[O:35])[N:26]=2)=[C:6]([C:7]([NH2:9])=[O:8])[CH:5]=1

Participants

4

Reactant 3

HCID 59525582HCID 59525582, compoundHCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 595259223-[(4-Bromo-2-pyrimidinyl)methyl]-2-oxazolidinone

Product 1

HCID 59526102HCID 59526102, compound

Procedure

The title compound was prepared according to Example 1 using 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (85 mg, 0.27 mmol) and the mixture of 3-[(4-chloropyrimidin-2-yl)methyl]-1,3-oxazolidin-2-one (21.5 mg, 0.10 mmol) and 3-[(4-bromopyrimidin-2-yl)methyl]-1,3-oxazolidin-2-one (44.2 mg, 0.17 mmol) as the starting materials.

Sources & evidence

ORD record
ord-be5e9d0b1dcb476a921b148e72c5862d
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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