4-Chloro-2-(pyrrolidin-1-yl)pyrimidine → 5-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-[(2-pyrrolidin-1-ylpyrimidin-4-yl)amino]thiophene-3-carboxamide

HRID 386098Notes

Reaction equation

HRID 386098 reaction equation
[NH2:1][C:2]1[S:3][C:4]([C:10]2[C:15]([F:16])=[CH:14][C:13]([C:17]([OH:20])([CH3:19])[CH3:18])=[CH:12][C:11]=2[F:21])=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8].Cl[C:23]1[CH:28]=[CH:27][N:26]=[C:25]([N:29]2[CH2:33][CH2:32][CH2:31][CH2:30]2)[N:24]=1>>[F:16][C:15]1[CH:14]=[C:13]([C:17]([OH:20])([CH3:18])[CH3:19])[CH:12]=[C:11]([F:21])[C:10]=1[C:4]1[S:3][C:2]([NH:1][C:27]2[CH:28]=[CH:23][N:24]=[C:25]([N:29]3[CH2:30][CH2:31][CH2:32][CH2:33]3)[N:26]=2)=[C:6]([C:7]([NH2:9])=[O:8])[CH:5]=1

Participants

3

Reactant 2

HCID 104877204-Chloro-2-(pyrrolidin-1-yl)pyrimidineHCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide

Product 1

HCID 595260375-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-[(2-pyrrolidin-1-ylpyrimidin-4-yl)amino]thiophene-3-carboxamide

Procedure

The title compound was prepared according to the general procedure in Example 1 using 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide and 4-chloro-2-pyrrolidin-1-ylpyrimidine as the starting materials.

Sources & evidence

ORD record
ord-6ee63e81b738459cb76081b408a2ef4f
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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