HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-2-(pyrrolidin-1-yl)pyrimidine → 5-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-[(2-pyrrolidin-1-ylpyrimidin-4-yl)amino]thiophene-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-2-(pyrrolidin-1-yl)pyrimidine | HCID 10487720 | — |
| Reactant | 2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide | HCID 59525619 | — |
| Product | 5-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-[(2-pyrrolidin-1-ylpyrimidin-4-yl)amino]thiophene-3-carboxamide | HCID 59526037 | — |
Reaction Steps
The title compound was prepared according to the general procedure in Example 1 using 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide and 4-chloro-2-pyrrolidin-1-ylpyrimidine as the starting materials.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08367706B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-6ee63e81b738459cb76081b408a2ef4f |
| Source note | uspto-grants-2013_02 |