反应详情

Twenty grams of 2-methoxy-4-methylmercapto-benzoic acid is dissolved in 260 ml of dimethylformamide, mixed with 13 gm of N,N'-carbonyl-diimidazole, and stirred for 30 minutes at ambient temperature. Then, 13 gm of 4,5-diamino-pyrimidin-2,6-dione are added, and the reaction mixture is refluxed for three hours with stirring. After cooling, it is poured into 1 liter of water. The product precipitated is suction filtered, washed with water, and dried at 70° C. in a circulating air drier.

1. temperaturethe reaction mixture is refluxed for three hours
2. stirringwith stirring
3. temperatureAfter cooling
4. customThe product precipitated
5. filtrationfiltered
6. washwashed with water
7. customdried at 70° C. in a circulating air drier