HCID 59525612, compound → HCID 59525935, compound

HRID 386103Notes

Reaction equation

HRID 386103 reaction equation
[NH2:1][C:2]1[S:3][C:4]([C:10]2[C:15]([F:16])=[CH:14][C:13]([C:17]([OH:20])([CH3:19])[CH3:18])=[CH:12][C:11]=2[F:21])=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8].Br[C:23]1[CH:28]=[CH:27][N:26]=[C:25]([CH2:29][N:30]2[CH:34]=[C:33]([Si:35]([CH3:38])([CH3:37])[CH3:36])[N:32]=[N:31]2)[N:24]=1.ClC1C=CN=C(CN2C=C([Si](C)(C)C)N=N2)N=1>>[F:16][C:15]1[CH:14]=[C:13]([C:17]([OH:20])([CH3:18])[CH3:19])[CH:12]=[C:11]([F:21])[C:10]=1[C:4]1[S:3][C:2]([NH:1][C:27]2[CH:28]=[CH:23][N:24]=[C:25]([CH2:29][N:30]3[CH:34]=[C:33]([Si:35]([CH3:38])([CH3:37])[CH3:36])[N:32]=[N:31]3)[N:26]=2)=[C:6]([C:7]([NH2:9])=[O:8])[CH:5]=1

Participants

4

Reactant 3

HCID 59525612HCID 59525612, compoundHCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 59526317HCID 59526317, compound

Product 1

HCID 59525935HCID 59525935, compound

Procedure

The title compound was prepared by the procedure in Example 1 using 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (62.3 mg, 0.200 mmol) and a mixture of 4-bromo-2-{[4-(trimethylsilyl)-1H-1,2,3-triazol-1-yl]methyl}pyrimidine (38 mg, 0.122 mmol) and 4-chloro-2-{[4-(trimethylsilyl)-1H-1,2,3-triazol-1-yl]methyl}pyrimidine (21 mg, 0.078 mmol) as the starting materials.

Sources & evidence

ORD record
ord-381f611e1d274caa9e373714d36a78fa
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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